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Revision as of 21:19, 3 November 2016

A different way to look at the battle against cancer

We are waging a battle against cancer where the focus is on killing the cancer. Maybe there is a better solution to the problem. Perhaps the focus should be on training the ummune system to kill the cancer rather than trying to kill the cancer directly.

Killing cancer might not be the best idea

The normal way to fight cancer has been to attack the cancer to kill it as hard as possible. When cancer returns you try to kill it again with something else, and then repeat to patient dies of either the cancer of the side effects of the treatment. Although this can buy some time, when it comes to the fatal cancers the cancer always wins in the long run.

Perhaps the idea of killing the cancer directly is a flawed idea. Maybe there's a better way? Maybe if we looked at what a cure for cancer might look like and then think backwards from the solution to the problem we can arrive at something that is more likely to be the cure?

I'm going to do a thought experiment here and I'm going to propose what I think the cure will be when lung cancer is cured, and then work backwards from the cure.

The cure for cancer is School - not War

I propose that the cure for stage 4 lung cancer is when the immune system is trained to recognize the cancer and all of it's mutations and kills the cancer and similar cells that are genetically and chemically related to the cancer. So the immune system is smart enough to recognize the cancer and all it's mutations so that the cancer can't evolve out of it.

So what mechanism can do that? The adaptive immune system. So if the above premise is correct - then the goal is to teach the adaptive immune system to recognize the cancer and all its variants and to be able to find and kill it. Therefore we need to forget about deliberately killing the cancer and focus on the training.

Since this is school and not war then perhaps we can take advantage of a new way of thinking. Rather than poison the patient to the verge of death in order to decimate the cancer as much as possible we can use lower dosages and take advantages of a lot more concurrent substances in combination, and sequence treatments in an order that is optimized for adaptive immune system training rather that a war on cancer strategy. The reader is now encouraged to forget the usual paradigms and to think more in low non-toxic dosages with few side effects for the purposes of maximizing training rather than killing.

Focus on the Training

Perhaps the goal should be focused on training the immune system to kill the cancer and focus on educating the immune system and not killing the cancer as the immediate goal.

In order for the immune system to learn cancer you need to:

1) Kill / wound enough cancer to allow the "smell" of the cancer to be out there for the adaptive immune system learn from. This is accomplished by:

a) Targeted kainase inhibitors (Caprelsa) at lower dosages to kill / wound cancer more slowly and reduce side effects.

b) Use mTor inhibitor combination to make targeted inhibitors more effective in low dosages.

c) Combination of

b) Radiation in low dosages - not to try to kill the tumor - but to kill / wound enough to create the smell of dying cancer.

2) Use combination of a low dose of Opdivo and Yervoy (Checkpoint inhibitors) to unmask the cancer